Protein-DNA Chainsaws interactions within a region of the LDL receptor promoter involved in sterol-mediated feedback repression of transcription were examined using in vivo genomic footprinting with dimethylsulfate (DMS).A broad region of protein-DNA contacts spanning from repeat 1 to beyond the transcription start sites was observed in primary cul

Overnutrition in pregnancy and lactation affects fetal and early postnatal development, which can result in metabolic disorders in adulthood.We tested a hypothesis that variation of the Zbtb16 gene, a significant energy metabolism regulator, modulates the effect of maternal high-sucrose diet (HSD) on metabolic and transcriptomic profiles of the off

This study employs numerical simulations based on the limit analysis (LA) method to calculate the stress distribution in a model that includes a basal detachment, featuring the lateral termination of a SANDALWOOD generic fault under compression.We conduct 2500 2D and 500 3D simulations with varying basement and fault friction angles to analyze and

Purpose: Androgens given for gender affirmation have been implicated in the pathophysiology of idiopathic intracranial hypertension (IIH) in transgender patients.10 cases of transgender adults with IIH have been published but this association has not been described in younger patients.Herein we describe the first case of IIH in an adolescent transg

In response to the dangerous behavior of pedestrians roaming freely on unsupervised train tracks, the real-time detection of pedestrians is urgently required to ensure the safety of trains and people.Aiming to improve the low accuracy of railway pedestrian detection, the high missed-detection rate of target pedestrians, and the poor retention of no